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146 Sapidolide A, extracted from a folk medicine used in China to treat inflammatory diseases, inhibits expression and activation of the NLRP3 inflammasome when used as a pretreatment in a mouse model of APAP-induced liver injury

USA 100 , 473477 (2003)

It also alters melanin production from eumelanin (dark pigment) to phaeomelanin (lighter pigment), which contributes to its skin-brightening effect.(2) This mechanism explains why its often promoted as a depigmenting agent for issues like melasma, sun spots, and post-inflammatory hyperpigmentation

Exosomes-derived miR-125-5p from cartilage endplate stem cells regulates autophagy and ECM metabolism in nucleus pulposus by targeting SUV38H1

ATP7A, which mediates dietary copper absorption in the intestine, and ATP7B, which promotes hepatic copper excretion, exert complementary functions that are critical for maintaining systemic copper homeostasis [84]