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In a clinical trial using third-generation HER2-CAR-T cells to treat a patient with metastatic colon cancer exhibiting HER2 overexpression, the patient succumbed 5 days post-treatment

Understanding different resistance mechanisms to currently-existing inhibitors can provide new insights into combinatorial targeting of the driver oncoprotein and further downstream effectors to avoid or postpone the therapy resistance

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10.1161/01.RES.0000130525.37646.a7 45

However, the loss of just PLC2 is sufficient to reduce ROS production to level slightly above resting cells (Li et al., 2000), suggesting that PLC2 is the primary mediator of superoxide production

J Basic Microbiol 54(Suppl 1):S190S199