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Inflammation in ulcerative colitis is localized to the mucosal and submucosal layers of the colon and rectum, whereas inflammation in CD can be found throughout the GI tract and affects all layers of the intestinal wall (transmural inflammation)

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In this regard, as 15LO1 increased, GPX4 expression concomitantly increased to balance the high 15LO1 activity (Figure 2C)

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