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Patients often report a gradual but positive change over weeks of therapy

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It functions in cellular signaling and lipid metabolism and has a role in serotonin signaling, which is the basis for the frequent claim that it curbs appetite

For histological analysis, the femoral and tibial condyles were fixed in 10% neutral buffered formalin, decalcified with 20% EDTA, embedded in paraffin, and sectioned into 5-m thick frontal slices

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Clinical experience suggests that some individuals experience increased tiredness, particularly during treatment initiation or dose escalation