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The prevalence of this disease is rising dramatically in the world, and the global prevalence of diabetes is about 8.8% (415 million) in 2015 [2]
Since l-tyrosine biotransformation is primarily dependent on tyrosinase activity, yield in this route could be improved by optimizing reaction conditions
Unfortunately, despite its high prevalence, a large number of MASLD cases remain undiagnosed, often leading to a diagnosis of cryptogenic cirrhosis, where MASH is the underlying condition once other etiological factors for chronic liver disease, such as alcohol abuse, viral hepatitis, autoimmune disorders, and other metabolic diseases, have been excluded [23]
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In addition, the membrane loss during splenic conditioning might further worsen the RBC metabolic setting, sustaining chronic hemolysis of HS
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