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3,3-dimethyl-1-butanol (DMB) is a structural analog of choline and an inhibitor for TMA formation through inhibition of microbial TMA lyases

Fermentation by a higher number of bacteria belonging to the Firmicutes and Bacteroidetes families is the cause of this impact [226]

4 ( ) : L- - 800 : , , ()

Simultaneously, it can transport Acetyl-CoA , a common product of the oxidation of fatty acids, branched-chain amino acids ( Leucine , isoleucine, and Valine ), and glucose, across the cell membrane in the form of acetylcarnitine, promoting the oxidative utilization of acetoacetate and playing a role in the elimination and utilization of ketone bodies

Therefore, TMAO is highly likely to be a significant risk factor in the onset of DKD

In elderly humans with senile dementia, daily oral administration of 2 g for 50 days slightly raised the plasma concentration of acetylcarnitine