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Protein kinases in neurodegenerative diseases: current understandings and implications for drug discovery

Preclinical safety data In mouse studies, 5-amino-1mq was well-tolerated even at doses several times higher than those producing metabolic effects

Although lipid peroxidation products (e.g., 4-HNE, MDA) and systemic iron parameters are altered in bodily fluids of AD patients (e.g., cerebrospinal fluid, blood), these markers lack disease and cell death modality specificity, as similar changes can occur in other neurodegenerative disorders or systemic pathological conditions

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doi: 10.3389/fpls.2020.575829 32 GhatakA.ChaturvediP.WeckwerthW