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Historical precedent matters here
if your pituitary cannot produce GH, sermorelin wont be effective (in such cases, hGH injections would be needed)
it is simply distributed across a slightly larger volume of solvent

This deficiency can cause anemia and in some cases, permanent neurologic damage

"Effect of epitalon on the lifespan increase in Drosophila melanogaster." Mechanisms of Ageing and Development

Man folks report having a massive improvement in memory function through out the day