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Description
While large human trials are pending, preclinical and mechanistic evidence is strong

**Weight and Fat Loss:** Step into the realm of fat loss with compelling rat study results showcasing significant reductions in body weight, lipogenesis rates, and cholesterol levels

(Nature, 2014) used an antisense oligonucleotide to knock down NNMT in mice and reported reduced fat-mass gain, better glucose tolerance, and lower liver triglycerides the founding paper for the whole NNMT-inhibitor field

Combined nicotinamide N-methyltransferase inhibition and lean-diet substitution reduces body weight and liver fat in obese mice

Most recommendations suggest consuming at least 0.7 to 1 gram of protein per pound of body weight daily

DNA damage: Accumulating mutations that impair gene expression
