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This concern arises from the fact that studies of hGH have shown that long-term exogenous administration, while increasing lean body mass and decreasing adipose tissue, can also cause: increased insulin resistance, diabetes, acromegaly, cancer, hypertension (high blood pressure), and edema (swelling)

Annu Rev Plant Biol 57:781803

Gynecol Obstet Invest

n=179 ALC, n=174 control), the pooled estimate was similarly in the direction favoring ALC (SMD 0.81, 95% CI 2.42 to 0.81

(114) is particularly significant as it examines the combined effects of total saponins from Stauntonia chinensis supplementation and aerobic exercise in a mouse model of NAFLD induced by a HFD