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doi: 10.1111/jnc.13425 58 YanNZhangJ

Hypoxia-induced deactivation of NGF-mediated ERK1/2 signaling in hippocampal cells: neuroprotection by acetyl-L-carnitine

The critical limitation: we don't know if these effects persist, resolve, or compound with continuous use beyond three months

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Once stabilized, NRF2 translocates to the nucleus, binds to AREs, and induces cytoprotective genes such as HO-1 , NQO1 , SLC7A11 , and GPX4 , which restore redox balance and limit lipid peroxidation [23]