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This is normal and indicates the peptide is hitting the receptors

Glycogenolysis is stimulated by even very small increases in extracellular K + concentrations above their normal level (Hof et al., 1988), and in astrocyte cultures pyruvate carboxylation is increased by an elevation of the K + concentration in the medium (Kaufman and Driscoll, 1993)

Science 123 , 309314 (1956)

doi: 10.1002/ijc.v129.2 195 CheungMKadariyaYTalarchekJPeiJOharJAKayalehORet al

Delta-sleep-inducing peptide (DSIP) stimulates the release of immunoreactive Met-enkephalin from rat lower brainstem slices in vitro

Hilfenhaus, G., Nguyen, D., Freshman, J., Prajapati, D., Ma, F., Song, D., Ziyad, S., Cuadrado, M., Pellegrini, M., Bustelo, X.R., and Iruela-Arispe, M.L., "VAV3-induced Cytoskeletal Dynamics Contribute to Heterotypic Properties of Endothelial Barriers", J Cell Biol 217 (8): 2813-2830 (2018)