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Monotherapy with aescin and its combination with PTU have shown significant efficacy in reducing hyperthyroidism, surpassing rutin alone or in combination with PTU

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Transdermal methods of oestrogen are generally preferred because they have a reduced risk of VTE compared to oral preparations

doi:10.1016/j.bmcl.2011.09.047 Yang WS, Stockwell BR (2008) Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells