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The resultant lethargy from heat stress often leads to decreased feeding and activity levels, further impacting on the productive performance of chickens, traditionally evidenced by a reduction in feed intake and altered carcass composition, notably a decrease in lean tissue and breast yield [32, 33]

10.1007/978-3-642-38007-5_15 169 UbedaF.OhtsukiH.GardnerA

Evidence suggests that T4 facilitates re-epithelialization and angiogenesis in various wound types, including burn wounds and diabetic ulcers, while also mitigating diabetes-associated neuropathy

Therefore, developing and validating biomarkers that directly indicate neuronal ferroptosissuch as specific oxidized phospholipid profiles, ferroptosis-related proteins (e.g., released HMGB1, modified GPX4), or their metabolic fragmentsis crucial for enhancing clinical diagnostic and therapeutic monitoring capabilities

And once we understood the mechanism, we could target it directly

Signal 11 , eaas9332 (2018)