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FIGURE 1 In this article, we will review how NRF2 activity is associated with neurodegenerative diseases, particularly with disease hallmarks such as oxidative stress, neuroinflammation and mitochondrial dysfunction

The C677T polymorphism (NCBI SNP cluster ID rs# 1801133) in MTHFR gene results in an alanine-to-valine (A222V) substitution which in turn causes a reduction in enzyme activity and subsequent elevation of plasma homocysteine [15, 16]

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These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds

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