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Exosomes are nano-sized vesicles that facilitate communication between cells

presented the concept of adjuvant-induced autoimmune/inflammatory syndrome (ASIA), which describes a series of immune-mediated disorders that can be developed in genetically predisposed individuals ( A classic example of ASIA is the autoimmune complications of immune checkpoint inhibitor (ICI) therapy used in cancer treatment, known as immune-related adverse events (irAEs) ( The main side effects of ICI therapy may include chronic fatigue, unrefreshing sleep, sleep disturbances, cognitive problems and memory loss in up to 42% of cases ( Vaccine-triggered autoimmune syndromes fall within the scope of the ASIA syndrome ( Although there are still no data on which adjuvants are involved in the development of autoimmune hypophysitis after vaccination against SARS-CoV-2, we suggest that vaccines using viral vectors could play an important role

Blood Adv 5(1):185-197, 2021

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Therefore, properties of the ECM, such as electro-conductivity, tissue-adaptive biomechanical properties, interfacial properties, stimulus responsiveness, mechano-electric coupling capacity, and so on, should be considered in the rational design process