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Furthermore, NAC-induced analgesia was abrogated by pharmacologic inhibition of Sxc or by the mGlu2/3 receptor antagonist, LY341495, suggesting that NAC alleviates chronic pain by amplifying the endogenous activation of mGlu2 receptors [166]

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29 Here we confirmed the early induction of GSTP1/P2 following PH and evidenced for the first time that this induction was associated with a predominant periportal intra-lobular localization