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doi: 10.1016/j.envint.2019.02.048, 30 LiX.FanL.WangX.YangY.ZhuY.HanX.et al

Chronic uremia inhibits the proliferation of endothelial progenitor cells, which are crucial for vascular repair
Vitamin B6 Supplementation : Like folic acid, vitamin B6 is a co-factor for the CBS enzyme

1993;265:R166R172

B12 is one important piece, but persistent exhaustion usually has more than one contributing factor