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63 The accumulated NAPQI depletes GSH in the endoplasmic reticulum to induce an oxidationreduction imbalance, which initiates the phosphorylation of eukaryotic initiation factor 2 (eIF2) to activate ATF6 and CHOP, eventually resulting in hepatocyte apoptosis (Figure 2)

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Activated IGF1R also increases Ku70 and Ku80 expression levels and thereby promotes DNA repair by NHEJ (Katayama et al., 2007) (Figure 4B)

If it arrives warm after shipping, move it into controlled cold storage promptly and document the arrival condition if the vial is part of a formal research workflow

Aging, stress, and environmental toxins often increase the body's demand for glutathione beyond what diet alone can provide