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Therefore, reduced butyrate levels increase the degradation of tight junction proteins

Future research is also needed to explore the antidepressant effects of LAC acting as part of a system network with other important mediators of brain plasticity in comparison with classical antidepressant drugs with particular focus on the effects in specific phenotypes of depression well-characterized not only for the individual endogenous levels of LAC but also for the corresponding changes in metabolic and inflammatory pathways as well as for history of adverse childhood experiences

doi: 10.1016/S0140-6736(24)02468-1 Allen Tingjun Yu, Jacob Dexter-Meldrum, Bharti Sharma, Luis Suarez-Rodriguez, Susan Talbert, Scott Ellis, Kusuma Nio, Navin D Bhatia, Raymond Wedderburn, Kate Twelker, George Agriantonis, Jennifer Whittington

37 Elevated PUFA levels facilitate LD budding, expansion, and fusion, so that the enlarged LDs can accommodate the excessive TAGs generated through enhanced lipogenesis