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The UPR is a signal transduction pathway that senses the fidelity of protein folding in the ER lumen (Naidoo et al

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Treatment at this stage requires dedicated biofilm disruption agents (N-acetylcysteine, serrapeptase, EDTA) before antifungals can be effective

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For sponsors and research partners operating internationally, staying aligned with the latest FDA directions is essential for designing high-quality, inspection-ready studies

19 Moreover, a recent study revealed that the gut microbiota-derived metabolites, such as secondary bile acids and p -cresol sulfate, were enriched in PD patients with RBD