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The NIH Office of Dietary Supplements, citing Institute of Medicine recommendations, advises that it is advisable for those older than 50 years to meet their RDA mainly by consuming foods fortified with vitamin B12 or a supplement containing vitamin B12. This recommendation reflects the fact that 10 to 30% of older adults lose the ability to efficiently absorb naturally occurring B12 from food

Either your diet is deficient, or the body cannot absorb it adequately due to the food you consume

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Each insertion introduces a small contamination risk

Interestingly, it is worth noticing that BBB as a carrier is extremely pivotal since glucose (also called fuel for the brain) transportation is vital for the appropriate functioning of the human brain and around 20% of the total body energy is used by the brain to work effectively [3, 6]
