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TADs are the first-line drugs for CVS prophylaxis and have been shown to reduce the duration, severity, and frequency of episodes, as well as the number of emergency room visits and hospitalizations.90 Amitriptyline, the TAD of choice, is usually started at a low dose of 25mg and is gradually increased to a target dose of approximately 100mg at night in adults

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With this premise, in the 1970s, Bystrm proposed procarbazine for the treatment of PD, but subsequent studies did not reveal any objective benefit

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Luo L, Ramanathan R, Horlbogen L, Mathialagan S, Costales C, Vourvahis M, et al