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When nicotine binds to 4 2 nAChR, it significantly enhances the firing rate and burst firing of dopamine neurons in the brain, thereby activating the mesolimbic dopamine system

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This ischemic environment can activate a series of intracellular cascade reactions, including excitotoxicity, inflammatory responses, glial cell activation, and neuronal apoptosis (67)

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Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities