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Funding This work was supported by grants from a DOD Career Development Award to Z.Q

Studies using polysomnography have documented increased slow-wave sleep duration and improved sleep efficiency in subjects administered DSIP, with some research showing up to 30% increases in delta wave activity during the first sleep cycles

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Further hydroxylation of tyrosine, combined with its decarboxylation leads to the catecholamine neurotransmitter dopamine , which in can be further derivatized to norepinephrine and epinephrine

In healthy states, gut bacteria are critical partners in energy extraction from ingested food, provide or regulate molecules used in communication between the gut and other organs, and act as a bulwark against incursions by pathogens [5]