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Humans and other eukaryotic organisms lack the enzymatic machinery necessary for de novo Cbl synthesis and rely on external sources, such as diet or symbiotic bacteria, to obtain Cbl [85, 86]

The suppressed-3-AR phenotype that AOD-9604 appeared to normalize in obese rodents may not carry the same weight in human adipose physiology

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(2014) Safety and Metabolism of AOD9604, a Novel Nutraceutical Ingredient for Improved Metabolic Health J Endocrinol Metab 4(1-2):114

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