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Numerous studies have shown that DTP cells can survive under therapeutic stress and gradually develop drug resistance through various complex mechanisms, including epigenetic reprogramming, transcriptome reprogramming, and metabolic remodeling ( 5.2 Promising new research directions DTP cells are cell cycle arrested and in a lower proliferation rates after being stressed by drugs

Anti-oxidant actions of selenium in orbital fibroblasts: a basis for the effects of selenium in Graves orbitopathy

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Gender-related differences in the clinical course of Crohns disease

And I think we are still learning this, because it just hasn't been around long enough for us to know what the long-term impacts are

Melatonin: Physiological effects in humans