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Introduction Melatonin is an endogenous indoleamine that is synthesized not only in the pineal gland (endocrine gland located in the posterior area of the cranial fossa in the brain in charge of producing melatonin and serotonin-derived hormones crucial in the modulation of sleep patterns in both circadian and seasonal cycles) but also perhaps in each individual cell, specifically at the mitochondrial level (Yanar et al., 2019)

Preclinical and limited human studies indicate DSIP may modulate the hypothalamicpituitaryadrenal (HPA) axis and support healthy cortisol rhythms, making it of interest in stress-related sleep disruption

Xiao Y, Zhu S, Yin W, Liu X, Hu Y

In vivo experiments further demonstrated that Irisin-loaded bone marrow mesenchymal stem cell-derived exosomes significantly inhibited activation of the YAP/EGR1/ACSL4 signaling pathway in the brains of middle cerebral artery occlusion (MCAO) mice, suppressed ferroptosis and lipid peroxidation, thereby mitigating ischemic brain injury ( In vitro experiments further confirmed that FGF21 protected HT22 cells from OGD/R-induced oxidative stress and ferroptosis, thereby attenuating neuronal injury ( In vivo experiments confirmed that 4 weeks of aerobic training significantly increased the expression of exosome miR-484 in the skeletal muscle of ischemic stroke rats