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However, the gaps in the available data from most animal experiments conducted to date have resulted in insufficient evidence to justify further clinical evaluations of the effects of LA on human poisoning cases

10 CurcioM.CirilloG.AmatoR.GuidottiL.AmanteaD.De LucaM.et al (2022)

HIF-1 is a transcriptional activator and a key regulator of the cellular adaptive responses to hypoxia and oxidative stress 25,26

2019 Jun 16;11(6):1356

Expression of human NAT1 has been detected in adult liver, bladder, digestive system, blood cells, placenta, skin, skeletal muscles, gingiva (Dupret & Lima, 2005), mammary tissue, prostate, and lung by a number of methods (Sim et al., 2008)