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In a mouse model of SCA6, BDNF and TrkB were downregulated at the age-at-onset, and early activation of TrkB-AKT signalling improved symptoms 59 , supporting our previously unappreciated findings whereby early manipulation of TrkB signalling regulated pathways in which GSH metabolism is crucial to halt the degenerative process triggered in iSPNs lacking BDNF-TrkB signalling

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After centrifugation (11, 000 rpm, 15 min, 4 C), protein concentrations were determined using a BCA assay

doi: 10.1038/s41565-021-00962-9 20 HouLTianCYanYZhangLZhangHZhangZ

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