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Previous studies on familial risk of lung cancer have shown that individuals with a first-degree relative suffering from lung cancer, multiple family members suffering from lung cancer, or relatives with early-onset lung cancer have an increased risk of developing the disease themselves

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In these cases, not maintaining a consistent daily injection schedule could lead to nerve damage

Instead, it is more likely that the expression of this mutant alters the numbers of GABA A Rs at inhibitory synapses, either through desensitization acting to regulate receptor number, or perhaps due to a homeostatic response to passing smaller Cl currents at synapses containing this mutant subunit during intense periods of synaptic activity