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Escalation phase breakdown The standard protocol starts low and increases every four weeks to minimize gastrointestinal side effects that rapid dose escalation can cause

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doi: 10.1038/NG1673 73 PerryDJPetersLDLakshmiPSZhangLHanZWasserfallCHet al

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Type 1 DM Pathophysiology: An autoimmune T-cellmediated destruction of pancreatic beta cells results in absolute insulin deficiency

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