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ROS and oxidative stress: origin and implication

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After axonal injury, disruption of the NAD + -binding site or destruction of the ARM-TIR interaction leads to constitutive activation of SARM1 characterized by the dimerization of the TIR domain, thereby consuming NAD + to generate mostly ADPR and NAM, but also a very small portion of cADPR

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J Neurophysiol 82(3):12861294 Sullivan JM (2000) Cellular and molecular mechanisms underlying learning and memory impairments produced by cannabinoids

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