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Human barrier recovery after acute acetone perturbation: an irritant dermatitis model

[56] Serum haptocorrin binds 80-90% of circulating B 12 , rendering it unavailable for cellular delivery by transcobalamin II

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Nevertheless, since GSH cannot be administered directlybecause of its insufficient absorption, stability and solubilityanalogues have been obtained, through modifications at the -glutamyl, cysteine and glycine moieties, and/or the functionalisation of the central cysteine, that are able to inhibit the activity of GSTs 69,87,105

Notably, GSH supplementation rescued the levels of downstream cysteine-related products (Extended Data Fig