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This dual role of lactate in modulating ferroptosis and inflammation may account for the inconsistent therapeutic outcomes associated with hypertonic sodium lactate administration in sepsis, as these effects appear to be highly dependent on factors such as timing of intervention, dosage and the specific experimental animal models employed (104,109)

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Mitusova K, Peltek OO, Karpov TE, Muslimov AR, Zyuzin MV, Timin AS

Furthermore, in animal models it appeared to improve the cognitive function and reduce amyloid deposition via thiamine-independent mechanisms, which are likely to include the suppression of glycogen synthase kinase-3 activities

doi: 10.1001/jama.1995.03530130055028 47

doi: 10.1159/000063573