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A recent review summarizes safety gaps and the regulatory context in the FDA context
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Systematic reviews of oral vitamin B12 therapy in vitamin B12 deficiency The first evidence-based analysis by the Vitamin B12 Cochrane Group in 2005 supports the efficacy of oral vitamin B12 as a curative treatment, with a dose between 1,000 and 2,000 g (1 and 2 mg) initially prescribed daily and then weekly [27]
The PAE procedure can lead to improvement in urination, with reduction of bothersome symptoms and improvement in quality of life
