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10.1038/nrn1938 Nat

Only a small fraction of allotopically expressed mitochondrial proteins localize to mitochondria 632,640 and functionally integrate, 641 likely due to the high hydrophobicity of these proteins, which hinders efficient mitochondrial import

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580 FlugeBrulandORisaKStorsteinAKristoffersenEKSapkotaDet al

The inner mitochondrial membrane is highly selective as to what will cross and is embedded with ion channels, SLC proteins, and other transporters responsible for translocating various molecules

doi: 10.1002/j.1939-4640.1995.tb00561.x, 220