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The labial cortical bone of mandibular incisors is significantly thinner than the posterior mandible, allowing the local anaesthetic to diffuse efficiently toward the terminal branches of the inferior alveolar nerve

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*Correspondence: Maria E

Post-simulation computation Following 100 ns MD simulation, initially, the last poses were collected from each simulation trajectory and analyzed for the displacement of docked ligand by comparison to the respective initial conformation using superimpose module in the free academic Maestro v12.6 tool of Schrdinger suite-2020.4 40