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Ehlers et al

Xanthine oxidase Xanthine oxidase (XO) is a flavin-containing isoenzyme of xanthine oxidoreductase (XOR) that catalyzes the oxidation of hypoxanthine to xanthine and, in the next step, xanthine to uric acid (Burrage et al

13, 54 Our mechanistic investigations demonstrated that BSO+L-PAM induced significant increases in mitochondrial depolarization, cleavage of caspase-3, caspase-9, poly ADP ribose polymerase and DNA fragmentation

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