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In addition, the ratio for aquatic hypoxia-tolerant mammals was much higher than that of terrestrial environment hypoxia-tolerant mammals

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However, we discovered that these peptides are also functional substrates of transglutaminase (TGM) 2, also called tissue TGM, and that structural disruption of the epidermis was repaired when these tetravalent peptides were applied topically as cross-linking substrates, regardless of possible interaction with MGL1 or MGL2

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