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Genetic variants in the MUT gene, causing MMA, can be divided into two types: (Mut-), a partial genetic variant in the MUT gene that results in low to moderate residual MUT activity in the presence of high concentrations of Adenosylcobalamin (AdoCbl), and (Mut0), a complete genetic variant in the MUT gene resulting in virtually undetectable MUT activity [12]

Moreover, we also searched preprint platform to avoid publication bias

doi: 10.1006/mgme.2000.3093

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161 There is limited evidence available demonstrating who is likely to respond well to EPAP, but it is generally not recommended for patients with severe obstructive sleep apnea, reduced airway size or lung volume, high risk for airway collapse, nasal obstruction, blood gas abnormalities, or for use after stroke