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Yes, and this is one of the most common reasons oral supplements stop working for people

"Systematic review and pragmatic clinical approach to oral and nasal vitamin B12 (cobalamin) treatment in patients with vitamin B12 deficiency related to gastrointestinal disorders"

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Treatment of adipocytes isolated from HSL-null mice with the beta-adrenergic agonist isoproterenol causes enhanced lipolysis, albeit at a blunted level compared with adipocytes from wild-type animals (91)

This condition, known as auto-brewery syndrome (ABS) (46), results from the endogenous production of ethanol through the fermentation of carbohydrates by microbes in the gastrointestinal system, oral cavity, and/or urinary tract (4749)