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Being the most common liver disease in developing and developed nations, NAFLD have been generally associated with obesity and the metabolic syndrome (MetS

Luo D, Chu X, Wu Y, Wang Z, Liao Z, Ji X, et al

In a 72-week, double-blind phase 2 trial in patients with biopsy-confirmed NASH (legacy term) and fibrosis stage F1F3, once-daily subcutaneous semaglutide produced dose-dependent NASH resolution: 59% at the 0.4 mg dose versus 17% with placebo (a statistically significant difference)

L.CintraE

In peripheral organs, enzymes involved in the generation and elimination of H 2 O 2 exhibit strong rhythmicity, which may collectively maintain the rhythmic oscillation of H 2 O 2

They are involved in respiratory chain oxidation, ATP generation, TCA catalyzation, fatty acids and pyruvate oxidization
