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Dosagens nos estudos animais: Na grande maioria dos estudos pr-clnicos, as doses utilizadas em ratos situam-se entre 10 g/kg e 10 ng/kg de peso corporal, administradas por via intraperitoneal ou oral

doi:10.1055/s-0041-1739967

For those with a mild deficiency or who can absorb B12 from food, oral Supplements or diet adjustments may be sufficient

Neuropeptide Y (NPY) in the area of the hypothalamic paraventricular nucleus activates the pituitaryadrenocortical axis in the rat

3 Another study showed that vitamin B12 levels were significantly lower after 4 months of treatment with isotretinoin for acne vulgaris

S.CollinsJ