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A decline in the dendritic spine density (DSD) is an early characteristic feature of many neurodegenerative diseases (Fiala et al., 2002

Choueiri TK, Escudier B, Powles T, Mainwaring PN, Rini BI, Donskov F, et al

An intervention that restores the body's own clock mechanism rather than patching over it is a meaningfully different proposition

Examples commonly listed in the category include: alcoholic myopathy drug-induced myopathy muscle cramps/spasms myalgia stiff-person syndrome Excludes2 (both can exist, both require documentation) Excludes2 means both conditions can exist at the same time, and both codes can be used when each is supported in the record

It is considered investigational, and human safety data is limited

An additional study (TERIS) utilizing teriflunomide 14 mg daily versus placebo also demonstrated a delay in time to the first clinical event in patients with radiologically isolated syndrome (64)