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Comparison with CRH-induced corticotropin and cortisol secretion

The combination consistently produces 3-8x baseline GH elevation in published models

Science 291 , 490493 (2001)

Biol Reprod

Stimulation with high intensity, presumably activating many afferent fibers, create large increases in [Na + ] i , which can spread throughout the whole cell and further to adjacent cells (Figure 2)

Treating SCD early enough to prevent disease onset in adult erythropoiesis eliminates the need for lifelong, non-curative treatment and significantly improves the quality of life for both the patient and their family