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These findings suggest that mitochondrial dysfunction-induced mtDNA release accelerates LUAD progression, particularly during senescence

Furthermore, IFN- from CD8 + T cells cooperates with fatty acids like arachidonic acid in the TME, driving tumor cell ferroptosis by upregulating the key lipid metabolism enzyme ACSL4 (138)

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Thats because of these limitations in how the body absorbs and utilises pharmacologically active substances

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