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New tools for Wilsons disease diagnosis: exchangeable copper fraction

Bobilev AM, Perez JM, Tamminga CA

Oxidation lays the foundation for the proliferation of free radicals and damage to cells, muscles, tissue, organs, etc

(Tewksbury, USA)

First, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs), a class of membrane-bound enzyme complexes that catalyzes the production of superoxides, contributes to iron-dependent accumulation of lipid peroxidation during ferroptosis ( Regulators of Iron Metabolism in Ferroptosis Although the exact mechanisms related to iron in ferroptosis remain obscure, there is no doubt about the key role of iron metabolism in the process of ferroptosis, because (1) Iron chelators block ferroptotic cell death in vitro and in vivo (Figure 1), which are discussed below