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The GLP-1 and GIP effects on pancreatic beta cells may also improve insulin secretion capacity beyond the effects of weight loss alone

Elderly patients may be more sensitive to the medications effects and may require slower titration or lower maintenance doses, particularly if they have reduced renal function or are at higher risk for dehydration from gastrointestinal adverse effects

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It also influences glucose uptake into muscle via insulin-receptor cross-talk, which is part of why protocols must be approached carefully pronounced hypoglycemia is a real consideration
