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Int J Biol Macromol 165(Pt B):31693179

Implications of the Study Although many regimes have been used in vitiligo treatment, there is still no permanent cure for this disease and the high cost also involved

Although we could not exclude the influence of different isolation procedures for each organ, along with the glutathione accumulation within TLS, these findings suggest that TLS in the kidney represent a unique microenvironment characterized by a dynamic equilibrium between oxidative stress and glutathione accumulation, which may play a pivotal role in regulating the formation of TLS and its function

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The pathological changes could also include altered brain metabolism, excitotoxicity, free radical generation, neuroinflammation, blood-brain barrier dysfunction, and apoptosis